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Registro Completo |
Biblioteca(s): |
Embrapa Amazônia Oriental. |
Data corrente: |
30/08/2017 |
Data da última atualização: |
22/12/2021 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
FIDELIS, Q. C.; CASTRO, R. N.; GUILHON, G. M. S. P.; RODRIGUES, S. T.; SALLES, C. M. C. de; SALLES, J. B. de; CARVALHO, M. G. de. |
Afiliação: |
Queli C. Fidelis, Universidade Federal Rural do Rio de Janeiro; Rosane N. Castro, Universidade Federal Rural do Rio de Janeiro; Giselle M. S. P. Guilhon, UFPA; SILVANE TAVARES RODRIGUES, CPATU; Cristiane M. C. de Salles, Universidade Federal Rural do Rio de Janeiro; João B. de Salles, UEZO; Mario G. de Carvalho, Universidade Federal Rural do Rio de Janeiro. |
Título: |
Flavonoids and other compounds from Ouratea ferruginea (Ochnaceae) as anticancer and chemopreventive agents. |
Ano de publicação: |
2012 |
Fonte/Imprenta: |
Molecules, v. 17, n. 7, p. 7989-8000, 2012. |
Idioma: |
Inglês |
Conteúdo: |
The chemical study of the extracts from leaves and stems of Ouratea ferruginea allowed the identification of a new isoflavone, 5-hydroxy-7,3′4′5′-tetramethoxyisoflavone, and twenty two known compounds, including friedelin, 3β-friedelinol, lupeone, a mixture of sitosterol, stigmasterol and campesterol, sitosteryl- and stigmasteryl-3-O-b-D-glucopyranosides, 5,4′-dihydroxy-7,5′,3′-trimethoxyisoflavone, 5,4′-dihydroxy-7,3′-di-methoxyisoflavone (7,3′-di-O-methylorobol), 5,7,4′-trihydroxy-3′,5′-dimethoxyisoflavone (piscigenin), 2R,3R-epicatechin, syringic acid, 2,6-dimethoxybenzoquinone, 2,6-dimethoxyhydroquinone, syringic and ferulic aldehyde, a mixture of vanillic acid, 1-hydroxy-2-methoxy-4-(1E-3-hydroxy-1-propenyl)-benzene and 3,5-dimethoxy-4-hydroxy-dihydrocinamaldehyde, besides amenthoflavone and 7-O-methylamenthoflavone (sequoiaflavone) which are considered as chemotaxonomic markers of Ouratea. The structures were identified by IR, 1H- and 13C-NMR and GC-MS, HPLC-MS, besides comparison with literature data. The inhibitory effects of 5,4′-dihydroxy-7,5′,3′-trimethoxyisoflavone, 7,3′-di-O-methylorobol, piscigenin and 7-O-methylamenthoflavone on cytochrome P450-dependent 7-ethoxycoumarin O-deethylase (ECOD) and glutathione S-transferase (GST) were evaluated in vitro. The 5,4′-dihydroxy-7,5′,3′-trimethoxy-isoflavone was the best inhibitor, inhibiting almost 75% of GST activity. Sequoiaflavone was the most potent inhibitor, inhibiting ECOD assay in 75%. These activities allow us to consider both these flavonoids as potential anticancer and chemopreventive agents. MenosThe chemical study of the extracts from leaves and stems of Ouratea ferruginea allowed the identification of a new isoflavone, 5-hydroxy-7,3′4′5′-tetramethoxyisoflavone, and twenty two known compounds, including friedelin, 3β-friedelinol, lupeone, a mixture of sitosterol, stigmasterol and campesterol, sitosteryl- and stigmasteryl-3-O-b-D-glucopyranosides, 5,4′-dihydroxy-7,5′,3′-trimethoxyisoflavone, 5,4′-dihydroxy-7,3′-di-methoxyisoflavone (7,3′-di-O-methylorobol), 5,7,4′-trihydroxy-3′,5′-dimethoxyisoflavone (piscigenin), 2R,3R-epicatechin, syringic acid, 2,6-dimethoxybenzoquinone, 2,6-dimethoxyhydroquinone, syringic and ferulic aldehyde, a mixture of vanillic acid, 1-hydroxy-2-methoxy-4-(1E-3-hydroxy-1-propenyl)-benzene and 3,5-dimethoxy-4-hydroxy-dihydrocinamaldehyde, besides amenthoflavone and 7-O-methylamenthoflavone (sequoiaflavone) which are considered as chemotaxonomic markers of Ouratea. The structures were identified by IR, 1H- and 13C-NMR and GC-MS, HPLC-MS, besides comparison with literature data. The inhibitory effects of 5,4′-dihydroxy-7,5′,3′-trimethoxyisoflavone, 7,3′-di-O-methylorobol, piscigenin and 7-O-methylamenthoflavone on cytochrome P450-dependent 7-ethoxycoumarin O-deethylase (ECOD) and glutathione S-transferase (GST) were evaluated in vitro. The 5,4′-dihydroxy-7,5′,3′-trimethoxy-isoflavone was the best inhibitor, inhibiting almost 75%... Mostrar Tudo |
Palavras-Chave: |
Agentes quimiopreventivos; Biflavonoides; Isoflavonas. |
Categoria do assunto: |
W Química e Física |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/163259/1/molecules-17-07989.pdf
|
Marc: |
LEADER 02407naa a2200229 a 4500 001 2074725 005 2021-12-22 008 2012 bl uuuu u00u1 u #d 100 1 $aFIDELIS, Q. C. 245 $aFlavonoids and other compounds from Ouratea ferruginea (Ochnaceae) as anticancer and chemopreventive agents.$h[electronic resource] 260 $c2012 520 $aThe chemical study of the extracts from leaves and stems of Ouratea ferruginea allowed the identification of a new isoflavone, 5-hydroxy-7,3′4′5′-tetramethoxyisoflavone, and twenty two known compounds, including friedelin, 3β-friedelinol, lupeone, a mixture of sitosterol, stigmasterol and campesterol, sitosteryl- and stigmasteryl-3-O-b-D-glucopyranosides, 5,4′-dihydroxy-7,5′,3′-trimethoxyisoflavone, 5,4′-dihydroxy-7,3′-di-methoxyisoflavone (7,3′-di-O-methylorobol), 5,7,4′-trihydroxy-3′,5′-dimethoxyisoflavone (piscigenin), 2R,3R-epicatechin, syringic acid, 2,6-dimethoxybenzoquinone, 2,6-dimethoxyhydroquinone, syringic and ferulic aldehyde, a mixture of vanillic acid, 1-hydroxy-2-methoxy-4-(1E-3-hydroxy-1-propenyl)-benzene and 3,5-dimethoxy-4-hydroxy-dihydrocinamaldehyde, besides amenthoflavone and 7-O-methylamenthoflavone (sequoiaflavone) which are considered as chemotaxonomic markers of Ouratea. The structures were identified by IR, 1H- and 13C-NMR and GC-MS, HPLC-MS, besides comparison with literature data. The inhibitory effects of 5,4′-dihydroxy-7,5′,3′-trimethoxyisoflavone, 7,3′-di-O-methylorobol, piscigenin and 7-O-methylamenthoflavone on cytochrome P450-dependent 7-ethoxycoumarin O-deethylase (ECOD) and glutathione S-transferase (GST) were evaluated in vitro. The 5,4′-dihydroxy-7,5′,3′-trimethoxy-isoflavone was the best inhibitor, inhibiting almost 75% of GST activity. Sequoiaflavone was the most potent inhibitor, inhibiting ECOD assay in 75%. These activities allow us to consider both these flavonoids as potential anticancer and chemopreventive agents. 653 $aAgentes quimiopreventivos 653 $aBiflavonoides 653 $aIsoflavonas 700 1 $aCASTRO, R. N. 700 1 $aGUILHON, G. M. S. P. 700 1 $aRODRIGUES, S. T. 700 1 $aSALLES, C. M. C. de 700 1 $aSALLES, J. B. de 700 1 $aCARVALHO, M. G. de 773 $tMolecules$gv. 17, n. 7, p. 7989-8000, 2012.
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Registro original: |
Embrapa Amazônia Oriental (CPATU) |
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Biblioteca(s): |
Embrapa Amazônia Ocidental. |
Data corrente: |
04/11/2016 |
Data da última atualização: |
04/11/2016 |
Tipo da produção científica: |
Comunicado Técnico/Recomendações Técnicas |
Autoria: |
MUNIZ, A. W.; NUNES, R. H. da S.; SILVA, T. A. C.; SÁ, E. L. S. de; CORDEIRO, E. R.; SILVA, K. E. da. |
Afiliação: |
ALEKSANDER WESTPHAL MUNIZ, CPAA; Ronielly Hádna da Silva Nunes, Bolsista de Iniciação Científica, Paic/Fapeam/Embrapa Amazônia Ocidental; Telma Andréa Carvalho Silva, Estudante em desenvolvimento de dissertação, bolsista do CNPq; Enilson Luiz Saccol de Sá, Universidade Federal do Rio Grande do Sul; EVERTON RABELO CORDEIRO, CPAA; KATIA EMIDIO DA SILVA, CPAA. |
Título: |
Carbono e atributos microbiológicos do solo em área desmatada da Amazônia no Rio Urucu, Coari, AM. |
Ano de publicação: |
2016 |
Fonte/Imprenta: |
Manaus: Embrapa Amazônia Ocidental, 2016. |
Páginas: |
4 p. |
Série: |
(Embrapa Amazônia Ocidental. Comunicado técnico, 122). |
ISSN: |
1517-3887 |
Idioma: |
Português |
Conteúdo: |
O objetivo do trabalho foi avaliar o carbono e os atributos microbiológicos do solo em uma área desmatada da Floresta Amazônica, na jazida petrolífera do Rio Urucu, no Município de Coari, AM. |
Thesagro: |
Microbiologia do Solo; Solo. |
Categoria do assunto: |
-- |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/149594/1/Com-Tec-122.pdf
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Marc: |
LEADER 00906nam a2200229 a 4500 001 2055887 005 2016-11-04 008 2016 bl uuuu u0uu1 u #d 022 $a1517-3887 100 1 $aMUNIZ, A. W. 245 $aCarbono e atributos microbiológicos do solo em área desmatada da Amazônia no Rio Urucu, Coari, AM.$h[electronic resource] 260 $aManaus: Embrapa Amazônia Ocidental$c2016 300 $a4 p. 490 $a(Embrapa Amazônia Ocidental. Comunicado técnico, 122). 520 $aO objetivo do trabalho foi avaliar o carbono e os atributos microbiológicos do solo em uma área desmatada da Floresta Amazônica, na jazida petrolífera do Rio Urucu, no Município de Coari, AM. 650 $aMicrobiologia do Solo 650 $aSolo 700 1 $aNUNES, R. H. da S. 700 1 $aSILVA, T. A. C. 700 1 $aSÁ, E. L. S. de 700 1 $aCORDEIRO, E. R. 700 1 $aSILVA, K. E. da
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